期刊
MOLECULES
卷 23, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules23030524
关键词
DprE1; virtual screening; tuberculosis; ADMET
资金
- CAMS Innovation Fund for Medical Sciences [CAMS-2017-I2M-1-011]
Decaprenylphosphoryl-beta-D-ribose oxidase (DprE1) is the flavoprotein subunit of decaprenylphosphoryl-D-ribose epimerase involved in cell wall synthesis in Mycobacterium tuberculosis and catalyzes the conversion of decaprenylphosphoryl ribose to decaprenylphosphoryl arabinose. DprE1 is a potential target against tuberculosis, including multidrug-resistant tuberculosis. We identified potential DprE1 inhibitors from the ChemDiv dataset through virtual screening based on pharmacophore and molecular docking. Thirty selected compounds were subjected to absorption, distribution, metabolism, excretion, and toxicity prediction with the Discovery Studio software package. Two compounds were obtained as hits for inhibiting DprEl activity in M. tuberculosis and are suitable for further in vitro and in vivo evaluation.
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