4.6 Article

A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

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MOLECULES
卷 23, 期 4, 页码 -

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MDPI
DOI: 10.3390/molecules23040770

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Lycium yunnanense Kuang; lyciumamide K; ECD calculations; antioxidant activities; oxygen radical absorbance capacity (ORAC) assay

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  1. National Natural Science Foundation of China [81573578]

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A new lignanamide (1), lyciumamide K, together with four known analogues (2-5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1-5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 +/- 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.

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