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CURRENT PHARMACEUTICAL DESIGN (2017)
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Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways
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CLINICAL SCIENCE (2016)
The tumor suppressor PTEN has a critical role in antiviral innate immunity
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CELL CYCLE (2016)
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PTEN recruitment controls synaptic and cognitive function in Alzheimer's models
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NATURE NEUROSCIENCE (2016)
PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine
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NEUROLOGICAL RESEARCH (2016)
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PHARMACOLOGICAL RESEARCH (2016)
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NATURE COMMUNICATIONS (2016)
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)
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BRAIN RESEARCH (2015)
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EXPERIMENTAL NEUROLOGY (2015)
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EXPERIMENTAL NEUROLOGY (2015)
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JOURNAL OF IMMUNOLOGY (2015)
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JOURNAL OF NEUROSCIENCE (2015)
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MOLECULAR MEDICINE REPORTS (2015)
PTEN Depletion Decreases Disease Severity and Modestly Prolongs Survival in a Mouse Model of Spinal Muscular Atrophy
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NEUROSCIENCE LETTERS (2015)
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HONG KONG MEDICAL JOURNAL (2014)
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JOURNAL OF NEUROSCIENCE (2013)
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PLOS ONE (2013)
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PLOS ONE (2013)
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PLOS ONE (2013)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)
Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway
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BASIC RESEARCH IN CARDIOLOGY (2012)
Functional analysis of the protein phosphatase activity of PTEN
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BIOCHEMICAL JOURNAL (2012)
An atypical patient with Cowden syndrome and PTEN gene mutation presenting with cortical malformation and focal epilepsy
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BRAIN & DEVELOPMENT (2012)
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INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2012)
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JOURNAL OF CHILD NEUROLOGY (2012)
Utility of PTEN Protein Dosage in Predicting for Underlying Germline PTEN Mutations among Patients Presenting with Thyroid Cancer and Cowden-Like Phenotypes
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
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NEUROLOGICAL RESEARCH (2012)
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PLOS ONE (2012)
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PLOS ONE (2012)
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PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model
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BLOOD (2011)
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CANCER RESEARCH (2011)
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation
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CELL DEATH AND DIFFERENTIATION (2011)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis
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INTERNATIONAL JOURNAL OF CANCER (2011)
Pharmacological Postconditioning Protects Against Hepatic Ischemia/Reperfusion Injury
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Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis
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STEM CELLS (2011)
A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression
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RESPIRATORY RESEARCH (2011)
Downregulation of PTEN at Corneal Wound Sites Accelerates Wound Healing through Increased Cell Migration
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)
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AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Oligodendrocyte PTEN Is Required for Myelin and Axonal Integrity, Not Remyelination
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ANNALS OF NEUROLOGY (2010)
The p85β regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
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DIABETES (2010)
PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet
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DIABETES (2010)
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
Sandra Jurado et al.
EMBO JOURNAL (2010)
PTEN/mTOR and axon regeneration
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EXPERIMENTAL NEUROLOGY (2010)
Redox regulation of the tumor suppressor PTEN by glutathione
Yujeong Kim et al.
FEBS LETTERS (2010)
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons
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HUMAN MOLECULAR GENETICS (2010)
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
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JOURNAL OF CLINICAL INVESTIGATION (2010)
Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination
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JOURNAL OF NEUROSCIENCE (2010)
Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, and pten Gene Deletion
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JOURNAL OF NEUROSCIENCE (2010)
PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons
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JOURNAL OF NEUROSCIENCE (2010)
Subtle variations in Pten dose determine cancer susceptibility
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NATURE GENETICS (2010)
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
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NATURE NEUROSCIENCE (2010)
Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
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NEUROSCIENCE LETTERS (2010)
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN
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ONCOGENE (2010)
Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models
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PLOS ONE (2010)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PTEN and TRP53 Independently Suppress Nanog Expression in Spermatogonial Stem Cells
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STEM CELLS AND DEVELOPMENT (2010)
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia
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BLOOD (2009)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia
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Protein Tyrosine Phosphatases Regulate Asthma Development in a Murine Asthma Model
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JOURNAL OF IMMUNOLOGY (2009)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
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SCIENCE (2008)
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Pradeep Reddy et al.
SCIENCE (2008)
Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcγR phagocytosis by prostaglandin E2 in alveolar macrophages
Claudio Canetti et al.
JOURNAL OF IMMUNOLOGY (2007)
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair
J-P Lai et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Differential redox regulation within the PTP superfamily
Sarah H. Ross et al.
CELLULAR SIGNALLING (2007)
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
Kulandayan K. Subramanian et al.
BLOOD (2007)
Inhibiting PTEN
E. Rosivatz
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Role of tumor suppressor PTEN in tumor necrosis factor α-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells.
Y. -T. Lo et al.
HORMONE AND METABOLIC RESEARCH (2007)
Protein tyrosine phosphatase inhibition reduces degeneration of dopaminergic substantia nigra neurons and projections in 6-OHDA treated adult rats
Peng Yang et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Lifelong accumulation of bone in mice lacking Pten in osteoblasts
Ximeng Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
Quan-Guang Zhang et al.
FEBS LETTERS (2007)
PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?
M. M. Mocanu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Min Zhao et al.
NATURE (2006)
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation
Kyung Sun Lee et al.
MOLECULAR PHARMACOLOGY (2006)
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
Xue Zhang et al.
FASEB JOURNAL (2006)
PTEN, a negative regulator of P13 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Fiona Kerr et al.
FEBS LETTERS (2006)
Selective deletion of Pten in pancreatic β cells leads to increased islet mass and resistance to STZ-induced diabetes
BL Stiles et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Lipid phosphatases as drug discovery targets for type 2 diabetes
DF Lazar et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 Pool
S Deleu et al.
CELLULAR SIGNALLING (2006)
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
SP Ji et al.
NATURE MEDICINE (2006)
PTEN levels in Alzheimer's disease medial temporal cortex
A Rickle et al.
NEUROCHEMISTRY INTERNATIONAL (2006)
A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)
Erika Rosivatz et al.
ACS CHEMICAL BIOLOGY (2006)
PTEN activity is modulated during ischemia and reperfusion - Involvement in the induction and decay of preconditioning
ZQ Cai et al.
CIRCULATION RESEARCH (2005)
TGFβ-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN
R Vogelmann et al.
JOURNAL OF CELL SCIENCE (2005)
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
ZB Chen et al.
NATURE (2005)
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
RJ Griffin et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations
MG Butler et al.
JOURNAL OF MEDICAL GENETICS (2005)
PPAR-gamma modulates allergic inflammation through upregulation of PTEN
KS Lee et al.
FASEB JOURNAL (2005)
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
C Kurlawalla-Martinez et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Muscle-specific Pten deletion protects against insulin resistance and diabetes
N Wijesekara et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The inositol 3-phosphatase PTEN negatively regulates Fcγ receptor signaling, but supports Toll-Like receptor 4 signaling in murine peritoneal macrophages
XH Cao et al.
JOURNAL OF IMMUNOLOGY (2004)
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
L Mahimainathan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Redox regulation of PTEN and protein tyrosine phosphatases in H2O2-mediated cell signaling
SH Cho et al.
FEBS LETTERS (2004)
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
M Raftopoulou et al.
SCIENCE (2004)
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) -: Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal
EA Orchiston et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
J Kwon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Bisperoxovanadium compounds are potent PTEN inhibitors
AC Schmid et al.
FEBS LETTERS (2004)
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
NR Leslie et al.
EMBO JOURNAL (2003)
Abnormal PTEN expression in portal hypertensive gastric mucosa: A key to impaired PI 3-kinase/Akt activation and delayed injury healing?
K Tsugawa et al.
FASEB JOURNAL (2003)
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
MA Crackower et al.
CELL (2002)
Reversible inactivation of the tumor suppressor PTEN by H2O2
SR Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
F Vazquez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6-pentakisphosphate 3-phosphatase activity
JJ Caffrey et al.
FEBS LETTERS (2001)
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