期刊
JOURNAL OF DIABETES & METABOLISM
卷 4, 期 9, 页码 -出版社
OMICS INT PVT LTD
DOI: 10.4172/2155-6156.1000301
关键词
Hepatitis C virus; Autoimmune diabetes mellitus; Type 1 diabetes mellitus; Latent autoimmune diabetes of adults
Hepatitis C virus infection and diabetes mellitus are two major public health problems worldwide and the burden of these diseases is expected to increase in the near future. Hepatitis C virus is associated to autoimmune disorders of several organs (e.g. thyroid and kidney) and has recently been reported to be associated also to metabolic disorders including type 2 diabetes mellitus. Biologically, the homologies between the hepatitis C virus polyprotein and the pancreas antigens could underlie a mechanism of molecular mimicry that could lead to autoimmune diabetes (type 1 diabetes mellitus and latent autoimmune diabetes of adults). Here we review the data on the potential relationship between HCV-related chronic liver disease and autoimmune mediated diabetes mellitus.
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