期刊
MOLECULAR PHARMACEUTICS
卷 15, 期 9, 页码 4049-4062出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.8b00473
关键词
magnetic polydopamine; multistage targeted; chemo-photothermal therapy; fluorescence/magnetic resonance imaging
资金
- National Natural Science Foundation of China [81772278]
- Special Funding of China Postdoctoral Science Foundation [2017T100472]
- China Postdoctoral Science Foundation [2016M602074]
Combination cancer therapy with various kinds of therapeutic approaches could improve the effectiveness of treatment while reducing side effects. Herein, we elaborately developed a theranostics nanoplatform based on magnetic polydopamine (MPDA) coated with hyaluronic acid methotrexate conjugates (MPDA@HA-MTX) for chemo-photothermal treatment (PTT). In this nanoplatform, Fe3O4 served as the core was applied as contrast agent for T-2-weighted magnetic resonance imaging (MRI) and early phase magnet targeting. Meanwhile, PDA was used as a versatile shell for effective loading of chemotherapeutic doxorubicin (DOX) to achieve controlled release and PTT simultaneously. Moreover, HA-MTX conjugates could offer later-phase specific cellular dual-targeting ability during the therapy. Both in vitro and in vivo studies demonstrated that DOX-loaded MPDA@HA-MTX (MPDA/DOX@HA-MTX) exhibited the preferential tumor accumulation, enhanced specificity to target tumor cells, pH-/laser-responsive release, and high tumor cell-killing efficiency. By combined chemo-PTT under the guidance of fluorescence/MR imaging, the tumors in mice were completely eliminated after treatment, indicating that MPDA@HA-MTX nanoparticles have great potential as a novel drug-loading platform for imaging guided multistage targeted chemo-photothermal combination therapy.
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