期刊
MOLECULAR PHARMACEUTICS
卷 15, 期 2, 页码 447-457出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.7b00808
关键词
tumor microenvironment; manganese dioxide; albumin-bound paclitaxel nanoparticles; chemoradiation therapy; magnetic resonance imaging; oxygenation
资金
- National Key Research and Development Program of China [2017YFA0205400]
- NSFC (Natural Science Foundation of China) [81473146, 81603043]
- State Key Laboratory of Natural Medicines [SKLNMKF201608]
- Central Fundamental Research Funds for the Central Universities
Tumor microenvironment with hypoxia and excess hydrogen peroxide (H2O2) tremendously limits the effect of chemoradiation therapy of colorectal cancer. For the first time, we developed a facile method to deposit manganese dioxide (MnO2) on the surface of albumin bound paclitaxel nanoparticles (ANPs-PTX) to obtain MnO2-functioned ANPs-PTX (MANPs-PTX). In the tumor microenvironment, MANPs-PTX could consume excess hydrogen peroxide (H2O2) to produce abundant oxygen for tumor oxygenation and improve chemoradiation therapy. Meanwhile, the released Mn2+ from MANPS-PTX had excellent T-1 magnetic resonance imaging (MRI) performances for tumor detection. Notably, the obtained MANPs-PTX would be a promising theranostic agent and have potential clinical application prospects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据