期刊
MOLECULAR PAIN
卷 14, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1744806918783943
关键词
Protein kinase M zeta; neuropathic pain; anterior cingulate cortex; chronic pain
资金
- National Research Foundation (NRF) of Korea grants - Korean government (MSIP) [NRF-2012R1A3A1050385, 2018R1C1B6008530]
- BK21 Research Fellowship from the Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea [2018R1C1B6008530] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Protein kinase M zeta is well known for its role in maintaining memory and pain. Previously, we revealed that the activation of protein kinase M zeta in the anterior cingulate cortex plays a role in sustaining neuropathic pain. However, the mechanism by which protein kinase M zeta is expressed in the anterior cingulate cortex by peripheral nerve injury, and whether blocking of protein kinase M zeta using its inhibitor, zeta inhibitory peptide, produces analgesic effects in neuropathic pain maintained chronically after injury, have not previously been resolved. In this study, we show that protein kinase M zeta expression in the anterior cingulate cortex is enhanced by peripheral nerve injury in a transcription-independent manner. We also reveal that the inhibition of protein kinase M zeta through zeta inhibitory peptide treatment is enough to reduce mechanical allodynia responses in mice with one-month-old nerve injuries. However, the zeta inhibitory peptide treatment was only effective for a limited time.
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