期刊
MOLECULAR NEUROBIOLOGY
卷 56, 期 2, 页码 1405-1420出版社
SPRINGER
DOI: 10.1007/s12035-018-1105-x
关键词
Neurodevelopment; Prefrontal cortex (PFC); 5-HT; TH; Cajal-Retzius
资金
- CAPES [BEX11914/13-0]
- Era-Net NEURON grant RESPOND
- Brazilian Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
Proper development of the medial prefrontal cortex (mPFC), crucial for correct cognitive functioning, requires projections from, among others, the serotonergic (5-HT) and catecholaminergic systems, but it is unclear how these systems influence each other during development. Here, we describe the parallel development of the 5-HT and catecholaminergic prefrontal projection systems in rat and demonstrate a close engagement of both systems in the proximity of Cajal-Retzius cells. We further show that in the absence of the 5-HT transporter (5-HTT), not only the developing 5-HT but also the catecholaminergic system, including their projections towards the mPFC, are affected. In addition, the layer identity of the mPFC neurons and reelin-positive interneuron number and integration are altered in the absence of the 5-HTT. Together, our data demonstrate a functional interplay between the developing mPFC 5-HT and catecholaminergic systems, and call for a holistic approach in studying neurotransmitter systems-specific developmental consequences for adult behavior, to eventually allow the design of better treatment strategies for neuropsychiatric disorders.
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