4.6 Review

Could Alzheimer's Disease Originate in the Periphery and If So How So?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

G. Morris et al.

MOLECULAR NEUROBIOLOGY (2018)

Review Behavioral Sciences

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

Gerwyn Morris et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Review Cell Biology

Autophagy pathway: Cellular and molecular mechanisms

Li Yu et al.

AUTOPHAGY (2018)

Review Cell Biology

Autophagy and Alzheimer's Disease

Qian Li et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)

Article Neurosciences

TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer's Disease Subjects

Ayano Mise et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Neurosciences

Alterations in the Peripheral Immune System in Dementia

Mandy Busse et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease

Lan Guo et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

Eric Tonnies et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease

Qian Cai et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Biochemistry & Molecular Biology

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Xiaorong Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Immunology

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Immunology

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

Axel Montagne et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Immunology

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Eleni Vergadi et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Clinical Neurology

Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies

Ka Sing P. Lai et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

Review Neurosciences

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

Annika Sommer et al.

MOLECULAR NEURODEGENERATION (2017)

Review Neurosciences

TREM2 in Neurodegenerative Diseases

Taylor R. Jay et al.

MOLECULAR NEURODEGENERATION (2017)

Article Clinical Neurology

Epidemiology and Causes of Parkinson's Disease

C. M. Lill et al.

NERVENARZT (2017)

Article Geriatrics & Gerontology

Brain tau deposition linked to systemic causes of death in normal elderly

Keith A. Josephs et al.

NEUROBIOLOGY OF AGING (2017)

Review Neurosciences

The blood-brain barrier in Alzheimer's disease

Elena Zenaro et al.

NEUROBIOLOGY OF DISEASE (2017)

Review Behavioral Sciences

A model of the mitochondrial basis of bipolar disorder

Gerwyn Morris et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Multidisciplinary Sciences

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

Mati Mann et al.

NATURE COMMUNICATIONS (2017)

Article Geriatrics & Gerontology

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

Li Zhong et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Article Geriatrics & Gerontology

The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease

Michela Guglielmotto et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Review Biotechnology & Applied Microbiology

mTOR-Dependent Cell Proliferation in the Brain

Larisa Ryskalin et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Multidisciplinary Sciences

Direct recognition of LPS drive TLR4 expressing CD8+ T cell activation in patients with rheumatoid arthritis

Archana Tripathy et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Gut microbiome alterations in Alzheimer's disease

Nicholas M. Vogt et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease

Neil D. Telling et al.

CELL CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Tyler K. Ulland et al.

Review Biochemistry & Molecular Biology

Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes

Leah Zuroff et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Review Gastroenterology & Hepatology

Influences of the Gut Microbiota on DNA Methylation and Histone Modification

Jianzhong Ye et al.

DIGESTIVE DISEASES AND SCIENCES (2017)

Review Immunology

The blood-brain barrier in systemic inflammation

Aravinthan Varatharaj et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

Article Clinical Neurology

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

Elizabeth Head et al.

CURRENT ALZHEIMER RESEARCH (2016)

Article Clinical Neurology

STAT3 SIGNALING REFEREES MICROGLIAL AMYLOID CLEARANCE IN ALZHEIMER’S DISEASE

Kevin R. Doty et al.

Alzheimers & Dementia (2016)

Article Clinical Neurology

Lymphocytes in Alzheimer's Disease Pathology: Altered Signaling Pathways

Noemi Esteras et al.

CURRENT ALZHEIMER RESEARCH (2016)

Article Clinical Neurology

The Putative Use of Lithium in Alzheimer's Disease

Gerwyn Morris et al.

CURRENT ALZHEIMER RESEARCH (2016)

Article Neurosciences

Alzheimer's Disease: Targeting the Cholinergic System

Talita H. Ferreira-Vieira et al.

CURRENT NEUROPHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

Karen J. Bryson et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

Review Neurosciences

Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

Lianne Hoeijmakers et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2016)

Review Biochemistry & Molecular Biology

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Abdel A. Belaidi et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Neurosciences

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

Masaaki Kobayashi et al.

JOURNAL OF NEUROSCIENCE (2016)

Article Immunology

Lymphocytes in Alzheimer's disease

Zoltan Fehervari

NATURE IMMUNOLOGY (2016)

Article Geriatrics & Gerontology

Determinants of iron accumulation in the normal aging brain

Lukas Pirpamer et al.

NEUROBIOLOGY OF AGING (2016)

Review Clinical Neurology

Dysfunction of NMDA receptors in Alzheimer's disease

Yan Zhang et al.

NEUROLOGICAL SCIENCES (2016)

Review Geriatrics & Gerontology

Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies

Isaac G. Onyango et al.

AGING AND DISEASE (2016)

Review Immunology

Imaging of Leukocyte Trafficking in Alzheimer's Disease

Enrica Pietronigro et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Clinical Neurology

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease

Gerard N. Bischof et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

Article Medicine, Research & Experimental

Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity

Xianfeng Wang et al.

JCI INSIGHT (2016)

Meeting Abstract Cardiac & Cardiovascular Systems

INFLUENCE OF APOLIPOPROTEIN E ISOFORM ON MICRORNA TRANSCRIPTOME IN MACROPHAGES

S. Czauderna et al.

ATHEROSCLEROSIS (2015)

Article Biochemistry & Molecular Biology

The blood-brain barrier endothelium: a target for pro-inflammatory cytokines

Keith D. Rochfort et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Review Biochemistry & Molecular Biology

An overview of molecular basis of iron metabolism regulation and the associated pathologies

Bruno Silva et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Medicine, General & Internal

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Gerwyn Morris et al.

BMC MEDICINE (2015)

Article Medicine, General & Internal

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Gerwyn Morris et al.

BMC MEDICINE (2015)

Article Neurosciences

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue

Kurt Lucas et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

Article Biochemistry & Molecular Biology

Impacts of oxidative stress on acetylcholinesterase transcription, and activity in embryos of zebrafish (Danio rerio) following Chlorpyrifos exposure

Gabriela Rodriguez-Fuentes et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

Charles C. Bailey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Endocrinology & Metabolism

Striatal blood-brain barrier permeability in Parkinson's disease

Madison T. Gray et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Genetics & Heredity

Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease

Atsushi Sasaki et al.

NEUROGENETICS (2015)

Article Neurosciences

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

Marie-Victoire Guillot-Sestier et al.

NEURON (2015)

Review Cell Biology

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

Seyedeh Maryam Alavi Naini et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Neurosciences

Autophagy in Alzheimer's disease

Ameneh Zare-shahabadi et al.

REVIEWS IN THE NEUROSCIENCES (2015)

Review Geriatrics & Gerontology

miR-155 is involved in Alzheimer's disease by regulating T lymphocyte function

Juhyun Song et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Review Behavioral Sciences

Epigenetic Alterations in Alzheimer's Disease

Josev. Sanchez-Mut et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2015)

Review Neurosciences

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Qinqin Wang et al.

TRANSLATIONAL NEURODEGENERATION (2015)

Review Endocrinology & Metabolism

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

Surapon Tangvarasittichai

WORLD JOURNAL OF DIABETES (2015)

Article Neurosciences

The APOE Gene is Differentially Methylated in Alzheimer's Disease

Jessica Foraker et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Review Endocrinology & Metabolism

Mitochondrial dysfunction and insulin resistance: an update

Magdalene K. Montgomery et al.

ENDOCRINE CONNECTIONS (2015)

Article Clinical Neurology

How does brain insulin resistance develop in Alzheimer's disease?

Fernanda G. De Felice et al.

ALZHEIMERS & DEMENTIA (2014)

Review Medicine, General & Internal

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

Kenneth Maiese

ANNALS OF MEDICINE (2014)

Article Pharmacology & Pharmacy

TREM2 and the neuroimmunology of Alzheimer's disease

Suzanne E. Hickman et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Review Biochemistry & Molecular Biology

Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer's and Parkinson's diseases

E. V. Stelmashook et al.

BIOCHEMISTRY-MOSCOW (2014)

Review Biochemistry & Molecular Biology

Is Alzheimer's disease a systemic disease?

Jill K. Morris et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

Xinglong Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Editorial Material Hematology

PP2A inactivation by ROS accumulation

Shingo Nakahata et al.

Article Multidisciplinary Sciences

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1-42)

J. Everett et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)

Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

Roberta Ward et al.

LANCET NEUROLOGY (2014)

Article Endocrinology & Metabolism

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

Xiaosong Yang et al.

MOLECULAR ENDOCRINOLOGY (2014)

Article Neurosciences

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Katie Lunnon et al.

NATURE NEUROSCIENCE (2014)

Review Cell Biology

Oxidative Stress in Alzheimer's Disease: Why Did Antioxidant Therapy Fail?

Torbjorn Persson et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Article Multidisciplinary Sciences

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

Mohammad Arif et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Neurosciences

Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications

Jijun Chen

REVIEWS IN THE NEUROSCIENCES (2014)

Review Neurosciences

Astrocytic modulation of blood brain barrier: perspectives on parkinson's disease

Ricardo Cabezas et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Geriatrics & Gerontology

Alzheimer's disease causation by copper toxicity and treatment with zinc

George J. Brewer

FRONTIERS IN AGING NEUROSCIENCE (2014)

Review Neurosciences

Protein phosphatase 2A dysfunction in Alzheimer's disease

Jean-Marie Sontag et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Review Neurosciences

GSK-3β, a pivotal kinase in Alzheimer disease

Maria Llorens-Martin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Review Pharmacology & Pharmacy

HFE gene variants, Iron, and lipids: a novel connection in Alzheimer's disease

Fatima Ali-Rahmani et al.

FRONTIERS IN PHARMACOLOGY (2014)

Editorial Material Clinical Neurology

Up-regulation of miRNA-146a in progressive, age-related inflammatory neurodegenerative disorders of the human CNS

Peter N. Alexandrov et al.

FRONTIERS IN NEUROLOGY (2014)

Review Neurosciences

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

Gary P. Morris et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Review Neurosciences

Microglial pathology

Wolfgang J. Streit et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Article Clinical Neurology

Microglia actions in Alzheimer’s disease

Stefan Prokop et al.

ACTA NEUROPATHOLOGICA (2013)

Review Immunology

Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective

Verena Wieser et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)

Article Clinical Neurology

Vascular Factors and Mitochondrial Dysfunction: a Central Role in the Pathogenesis of Alzheimer’s Disease

Daniele Orsucci et al.

CURRENT NEUROVASCULAR RESEARCH (2013)

Review Geriatrics & Gerontology

Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review

Maria Markaki et al.

GERONTOLOGY (2013)

Article Biochemistry & Molecular Biology

Epigenetic signature and enhancer activity of the human APOE gene

Chang-En Yu et al.

HUMAN MOLECULAR GENETICS (2013)

Review Biochemistry & Molecular Biology

The Role of Metallothionein in Oxidative Stress

Branislav Ruttkay-Nedecky et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Biochemistry & Molecular Biology

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis IMPLICATION FOR ALZHEIMER DISEASE

Zhi Tang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Editorial Material Biochemistry & Molecular Biology

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease

Gunnar K. Gouras

JOURNAL OF NEUROCHEMISTRY (2013)

Article Geriatrics & Gerontology

Neuroinflammatory phenotype in early Alzheimer's disease

Tiffany L. Sudduth et al.

NEUROBIOLOGY OF AGING (2013)

Article Biochemistry & Molecular Biology

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

Chuang Guo et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Review Biochemistry & Molecular Biology

Metal dyshomeostasis and oxidative stress in Alzheimer's disease

Mark A. Greenough et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

Article Medicine, General & Internal

TREM2 Variants in Alzheimer's Disease

Rita Guerreiro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Cell Biology

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Yan Zhao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Multidisciplinary Sciences

Alzheimer's Disease: Analyzing the Missing Heritability

Perry G. Ridge et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease

Julio Acosta-Cabronero et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

Samuel I. A. Cohen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Clinical Neurology

Autophagic/lysosomal dysfunction in Alzheimer's disease

Miranda E. Orr et al.

ALZHEIMERS RESEARCH & THERAPY (2013)

Review Clinical Neurology

The role of APP and BACE1 trafficking in APP processing and amyloid-beta generation

Xiaojie Zhang et al.

ALZHEIMERS RESEARCH & THERAPY (2013)

Review Geriatrics & Gerontology

A delicate balance: Iron metabolism and diseases of the brain

Dominic Hare et al.

FRONTIERS IN AGING NEUROSCIENCE (2013)

Article Education, Scientific Disciplines

Iron and hepcidin: a story of recycling and balance

Clara Camaschella

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2013)

Article Immunology

Lipopolysaccharide induces IFN-gamma production in human NK cells

Leonid M. Kanevskiy et al.

FRONTIERS IN IMMUNOLOGY (2013)

Article Neurosciences

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

Sharon C Yates et al.

Acta Neuropathologica Communications (2013)

Review Biochemistry & Molecular Biology

Synaptic Mitochondrial Pathology in Alzheimer's Disease

Heng Du et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Review Biochemistry & Molecular Biology

Hepcidin and iron homeostasis

Tomas Ganz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Review Microbiology

Intestinal Commensal Microbes as Immune Modulators

Ivaylo I. Ivanov et al.

CELL HOST & MICROBE (2012)

Article Clinical Neurology

AICD Nuclear Signaling and Its Possible Contribution to Alzheimer's Disease

Uwe Konietzko

CURRENT ALZHEIMER RESEARCH (2012)

Article Clinical Neurology

Roles of Glycogen Synthase Kinase 3 in Alzheimer's Disease

Zhiyou Cai et al.

CURRENT ALZHEIMER RESEARCH (2012)

Article Neurosciences

Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood

Katie Lunnon et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Biochemistry & Molecular Biology

Sustained Submicromolar H2O2 Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

Gunda Millonig et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

James G. Cash et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

Sven O. Dahms et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Proteolytic processing of Alzheimer's ss-amyloid precursor protein

Han Zhang et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Immunology

Immune profiling of Alzheimer patients

Mariavaleria Pellicano et al.

JOURNAL OF NEUROIMMUNOLOGY (2012)

Article Neurosciences

Peripheral Mitochondrial Dysfunction in Alzheimer's Disease: Focus on Lymphocytes

Kristina Leuner et al.

MOLECULAR NEUROBIOLOGY (2012)

Article Multidisciplinary Sciences

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Robert D. Bell et al.

NATURE (2012)

Article Multidisciplinary Sciences

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

Joseph M. Reynolds et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Immunology

The Role of Natural Killer Cells in Alzheimer's Disease

F. Jadidi-Niaragh et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2012)

Review Neurosciences

T cell recruitment in the brain during normal aging

Jickssa M. Gemechu et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2012)

Article Medicine, Research & Experimental

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

David M. Holtzman et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Neurosciences

GSK3 as a sensor determining cell fate in the brain

Adam R. Cole

FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)

Review Neurosciences

A pivotal role of GSK-3 in synaptic plasticity

Clarrisa A. Bradley et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)

Review Pharmacology & Pharmacy

Microglia function in Alzheimer's disease

Egle Solito et al.

FRONTIERS IN PHARMACOLOGY (2012)

Article Cell Biology

Oxidative stress in neurodegenerative diseases

Xueping Chen et al.

NEURAL REGENERATION RESEARCH (2012)

Review Neurosciences

Amyloid Precursor Protein Processing and Alzheimer's Disease

Richard J. O'Brien et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Article Biochemistry & Molecular Biology

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

Cristian A. Lasagna-Reeves et al.

FEBS LETTERS (2011)

Article Biochemistry & Molecular Biology

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

Beinan Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2' mapping

Yuanyuan Qin et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2011)

Article Biochemical Research Methods

Oxidative stress-mediated regulation of proteasome complexes

C. T. Aiken et al.

MOLECULAR & CELLULAR PROTEOMICS (2011)

Article Clinical Neurology

Proinflammatory cytokines, sickness behavior, and Alzheimer disease

C. Holmes et al.

NEUROLOGY (2011)

Review Neurosciences

APP processing in Alzheimer's disease

Yun-Wu Zhang et al.

MOLECULAR BRAIN (2011)

Article Clinical Neurology

Molecular interplay between mTOR, Aβ and tau: Effects on cognitive impairments

Salvatore Oddo

Alzheimers & Dementia (2010)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

Paula I. Moreira et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Article Neurosciences

A Meta-Analysis of Cytokines in Alzheimer's Disease

Walter Swardfager et al.

BIOLOGICAL PSYCHIATRY (2010)

Article Neurosciences

Vitamin B12 Levels in Alzheimer's Disease: Association with Clinical Features and Cytokine Production

Antonis Politis et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Review Neurosciences

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

Russell H. Swerdlow et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Biochemistry & Molecular Biology

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

Hyun-Hee Cho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS

Antonella Caccamo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Metals, oxidative stress and neurodegenerative disorders

Klaudia Jomova et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)

Review Food Science & Technology

Implications of apolipoprotein E genotype on inflammation and vitamin E status

Patricia Huebbe et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2010)

Review Clinical Neurology

Astrocytes in Alzheimer's Disease

Alexei Verkhratsky et al.

NEUROTHERAPEUTICS (2010)

Article Multidisciplinary Sciences

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

Marta M. Lipinski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Immunology

Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide

Jeremy P. McAleer et al.

TRENDS IN IMMUNOLOGY (2010)

Review Geriatrics & Gerontology

Selective neuronal vulnerability to oxidative stress in the brain

Xinkun Wang et al.

FRONTIERS IN AGING NEUROSCIENCE (2010)

Review Cell Biology

mTOR's role in ageing: protein synthesis or autophagy?

Sarah L. Hands et al.

AGING-US (2009)

Review Biochemistry & Molecular Biology

Oxidative Stress and Autophagy in the Regulation of Lysosome-Dependent Neuron Death

Violetta N. Pivtoraiko et al.

ANTIOXIDANTS & REDOX SIGNALING (2009)

Article Pharmacology & Pharmacy

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

Cinzia Dello Russo et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Review Biochemistry & Molecular Biology

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

Catherine M. Cahill et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Review Biochemistry & Molecular Biology

Astroglia in dementia and Alzheimer's disease

J. J. Rodriguez et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Immunology

Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex

Mousa Komai-Koma et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

Long Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Neurosciences

Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

Anis Larbi et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

Review Neurosciences

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

Sandro Altamura et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

Editorial Material Cell Biology

mTOR signaling at a glance

Mathieu Laplante et al.

JOURNAL OF CELL SCIENCE (2009)

Article Clinical Neurology

Systemic inflammation and disease progression in Alzheimer disease

C. Holmes et al.

NEUROLOGY (2009)

Article Cell Biology

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

Lisa Mosconi et al.

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

Article Immunology

Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease

Hiroaki Taguchi et al.

AUTOIMMUNITY REVIEWS (2008)

Article Immunology

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk

Susana Minguet et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Hydrogen peroxide promotes Aβ production through JNK-dependent activation of γ-secretase

Chengyong Shen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Cell Biology

The ubiquitin-proteasome system in Alzheimer's disease

Salvatore Oddo

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Review Cell Biology

A potential pathogenetic role of iron in Alzheimer's disease

Laura Silvestri et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Medicine, Research & Experimental

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Marta Martinez-Vicente et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Biochemistry & Molecular Biology

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

P. Hemachandra Reddy et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Article Biochemistry & Molecular Biology

The GSK3 hypothesis of Alzheimer's disease

Claudie Hooper et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Article Multidisciplinary Sciences

mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex

John T. Cunningham et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Oxidative inhibition of protein phosphatase 2A activity: Role of catalytic subunit disulfides

Timothy D. Foley et al.

NEUROCHEMICAL RESEARCH (2007)

Article Public, Environmental & Occupational Health

Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study

F. D. Dick et al.

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2007)

Article Neurosciences

Expression of APP pathway mRNAs and proteins in Alzheimer's disease

Toshifumi Matsui et al.

BRAIN RESEARCH (2007)

Review Clinical Neurology

Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment

William R. Markesbery et al.

ARCHIVES OF NEUROLOGY (2007)

Review Neurosciences

Intracellular amyloid-β in Alzheimer's disease

Frank M. LaFerla et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression

Laia Jofro-Monseny et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Clinical Neurology

Variations in the APP gene promoter region and risk of Alzheimer disease

L. Guyant-Marechal et al.

NEUROLOGY (2007)

Article Immunology

Systemic infections and inflammation affect chronic neurodegeneration

V. Hugh Perry et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Review Cell Biology

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide

Christian Haass et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Clinical Neurology

Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease

Qunxing Ding et al.

CURRENT ALZHEIMER RESEARCH (2007)

Article Gastroenterology & Hepatology

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo

Antonello Pietrangelo et al.

GASTROENTEROLOGY (2007)

Article Hematology

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Maria Vittoria Verga Falzacappa et al.

Article Neurosciences

GSK3α exhibits β-catenin and tau directed kinase activities that are modulated by Wnt

Ayodeji A. Asuni et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

Article Hematology

Interleukin induces hepcidin expression through STAT3

Diedra M. Wrighting et al.

Article Biochemistry & Molecular Biology

Furin is an endogenous regulator of α-secretase associated APP processing

Eun Mi Hwang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Biochemistry & Molecular Biology

The role of iron regulatory proteins in mammalian iron homeostasis and disease

Tracey A. Rouault

NATURE CHEMICAL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide

Marc Mikhael et al.

FEBS JOURNAL (2006)

Review Multidisciplinary Sciences

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology including Alzheimer's disease

RW Mahley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Geriatrics & Gerontology

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

HM Schipper et al.

NEUROBIOLOGY OF AGING (2006)

Article Geriatrics & Gerontology

Association between glycogen synthase kinase-3 beta genetic polymorphism and late-onset Alzheimer's disease

I Mateo et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2006)

Article Geriatrics & Gerontology

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

M Mishto et al.

NEUROBIOLOGY OF AGING (2006)

Article Multidisciplinary Sciences

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

SJ Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Mitochondrial Aβ:: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

C Caspersen et al.

FASEB JOURNAL (2005)

Article Biochemistry & Molecular Biology

Astrocytes: regulation of brain homeostasis via apolipoprotein E

JR Gee et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Review Neurosciences

T-cells in Alzheimer's disease

T Town et al.

NEUROMOLECULAR MEDICINE (2005)

Article Biochemistry & Molecular Biology

Gene structure and organization of the human β-secretase (BACE) promoter

K Sambamurti et al.

FASEB JOURNAL (2004)

Article Multidisciplinary Sciences

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

EM Blalock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

EM Reiman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Multidisciplinary Sciences

Pathways towards and away from Alzheimer's disease

MP Mattson

NATURE (2004)

Article Biochemistry & Molecular Biology

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Aβ peptides

XD Huang et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Apolipoprotein E and β-amyloid (1-42) regulation of glycogen synthase kinase-3β

A Cedazo-Mínguez et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Article Multidisciplinary Sciences

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

CJ Phiel et al.

NATURE (2003)

Letter Biochemistry & Molecular Biology

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

LB Yang et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue

TB Shea et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)

Article Clinical Neurology

Atypical inflammation in the central nervous system in prion disease

VH Perry et al.

CURRENT OPINION IN NEUROLOGY (2002)

Article Biochemistry & Molecular Biology

Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice

KT Suzuki et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

The influence of oxidation of membrane thiol groups on lysosomal proton permeability

FY Wan et al.

BIOCHEMICAL JOURNAL (2001)

Article Biochemistry & Molecular Biology

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

AL Bulteau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Degradation of oxidized proteins by the 20S proteasome

KJA Davies

BIOCHIMIE (2001)

Article Biochemistry & Molecular Biology

Redox-active iron mediates amyloid-β toxicity

CA Rottkamp et al.

FREE RADICAL BIOLOGY AND MEDICINE (2001)

Article Neurosciences

Lysosomal membrane damage in soluble Aβ-mediated cell death in Alzheimer's disease

K Ditaranto et al.

NEUROBIOLOGY OF DISEASE (2001)

Article Biochemistry & Molecular Biology

Oxidative regulation of fatty acid-induced tau polymerization

TC Gamblin et al.

BIOCHEMISTRY (2000)