期刊
MOLECULAR IMMUNOLOGY
卷 101, 期 -, 页码 155-159出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2018.06.270
关键词
MAIT cells; MR1; Innate immunity; Pulmonary infection
资金
- Deutsche Forschungsgemeinschaft [HA 7558/1-1]
- US NIH grant [R01 AI129976, AI 71922, AI 105215, AI 137230]
Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAST cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.
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