期刊
MOLECULAR DIVERSITY
卷 22, 期 2, 页码 503-516出版社
SPRINGER
DOI: 10.1007/s11030-017-9811-2
关键词
Ugi reaction; Nitrogen-containing heterocycle; Polyazaheterocycle; Multicomponent reactions; Cyclization; Review
Isocyanide-based multicomponent reactions are among the most powerful synthetic tools available. Particularly, the isocyanide-based Ugi reaction can allow rapid preparation of -aminoacyl amide derivatives and polyazaheterocycles with extensive pharmaceutical applications. Moreover, bridged polyazaheterocycles, including one or more quaternary carbon centers, can be constructed via the Ugi cascade reaction in a few steps. This review will emphasize synthesis and bioactivities of bridged compounds with quaternary centers constructed through Ugi cascade reactions.
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