期刊
MOLECULAR ASPECTS OF MEDICINE
卷 59, 期 -, 页码 36-46出版社
ELSEVIER
DOI: 10.1016/j.mam.2017.07.003
关键词
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资金
- EU Joint Programme for Neurodegenerative Disease (JPND) [529-2014-7500]
- Swedish Medical Research Council [2016-02112]
- Ahlen-stiftelsen [MA1/h16]
- Birgit Backmark's Donation
- Parkinsonfonden [910/16]
- Ulla-Carin Lindquists stiftelse
- NEURO Sweden
- Magnus Bergvalls stiftelse [2016-01531]
- Strategic Research Area Neuroscience (StratNeuro)
- Swedish Research Council [E0287001]
- Svenska Sallskapet for Medicinska Forskning (SSMF)
- Jeanssons Stiftelser
- Ake Wiberg Stiftelser [M16-0015]
- Karolinska Institutet Foundation [2016fobi47682]
- Vinnova [2016-02112] Funding Source: Vinnova
- Formas [2016-02112] Funding Source: Formas
- Swedish Research Council [2016-02112] Funding Source: Swedish Research Council
Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and decompose tissues into cell types and/or cell states, which offers enormous potential for de novo discovery. Single-cell transcriptomic atlases provide unprecedented resolution to reveal complex cellular events and deepen our understanding of biological systems. In this review, we summarize and compare single-cell RNA sequencing technologies, that were developed since 2009, to facilitate a well-informed choice of method. The applications of these methods in different biological contexts are also discussed. We anticipate an ever-increasing role of single-cell RNA sequencing in biology with further improvement in providing spatial information and coupling to other cellular modalities. In the future, such biological findings will greatly benefit medical research. (C) 2017 Elsevier Ltd. All rights reserved.
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