期刊
MOLECULAR ASPECTS OF MEDICINE
卷 60, 期 -, 页码 69-80出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mam.2017.12.002
关键词
Extracellular vesicles; Trophoblast; Preeclampsia; Pregnancy; Human
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [3160194, 1150377]
- Comision Nacional de Investigacion y Desarrollo (CONICYT)-Chile
- Faculty of Medicine, PUC-PhD fellowships, Chile
Intercellular communication is a critical process in biological mechanisms. During pregnancy foetopla-cental tissues release a heterogeneous group of extracellular vesicles (EVs) that include exosomes, microvesicles, apoptotic bodies, and syncytial nuclear aggregates. These vesicles contain a complex cargo (proteins, DNA, mRNA transcripts, microRNAs, noncoding RNA, lipids, and other molecules) that actively participate in the maternal-foetal communication by modulating different processes during gestation for a successful foetal development. Each stage of human gestation is marked by events such as immuno-modulation, proliferation, invasion, migration, and differentiation, among others, requiring EVs-mediated signalling to be nearby or distant target cells. Furthermore, EVs also associate with pregnancy pathologies such as preeclampsia and intrauterine growth restriction. This review addresses the role of EVs in human foetomaternal communication in normal pregnancy and preeclampsia. (c) 2017 Elsevier Ltd. All rights reserved.
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