期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 466, 期 -, 页码 2-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.08.011
关键词
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资金
- National Breast Cancer Foundation [ECF-16-007, PS-16-023]
- Cure Cancer Australia Foundation/Cancer Australia [APP1098796]
- National Health and Medical Research Council [APP1081334]
- Cancer Council NSW [RG-15-17]
- Worldwide Cancer Research [13-1169]
The ovarian hormones estrogen and progesterone are master regulators of the development and function of a broad spectrum of human tissues, including the breast, reproductive and cardiovascular systems, brain and bone. Acting through the nuclear estrogen (ER) and progesterone receptors (PR), both play complex and essential coordinated roles in the extensive development of the lobular alveolar epithelial structures of the normal breast during puberty, the normal menstrual cycle and pregnancy. The past decade has seen major advances in understanding the mechanisms of action of estrogen and progesterone in the normal breast and in the delineation of the complex hierarchy of cell types regulated by ovarian hormones in this tissue. There is evidence for a role for both ER and PR in driving breast cancer, and both are favourable prognostic markers with respect to outcome. In this review, we summarize current knowledge of the mechanisms of action of ER and PR in the normal breast, and implications for the development and management of breast cancer. (C) 2017 Elsevier B.V. All rights reserved.
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