期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 468, 期 -, 页码 39-46出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.12.013
关键词
Leydig cell; Genome-wide analysis; Reprogramming
资金
- MEXT KAKENHI [17H06427, 16H05142, 16K08593, 17J03270]
- Takeda Science Foundation
- Shin-Nihon of Advanced Medical Research Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [16K08593, 17H06427, 17J03270, 16H05142] Funding Source: KAKEN
Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells. (C) 2018 Elsevier B.V. All rights reserved.
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