期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 466, 期 -, 页码 15-30出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.09.014
关键词
Aromatase; Breast cancer; Obesity; Estrogen; Inflammation
资金
- Victorian Government Operational Infrastructure Support Program
- Mavis Robertson Fellowship from the National Breast Cancer Foundation (NBCF) [ECF-16-004]
- NBCF Novel Concept Award [NC-14-011]
- NHMRC [GNT1061800]
- BeIPD-Marie Curie COFUND fellowship from the University of Liege, Belgium
One in eight women will develop breast cancer over their lifetime making it the most common female cancer. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity is now an accepted risk factor for breast cancer in postmenopausal women, particularly for the hormone-dependent subtype of breast cancer. Obesity, which is characterized by an excess accumulation of body fat, is at the origin of chronic inflammation of white adipose tissue and is associated with dramatic changes in the biology of adipocytes leading to their dysfunction. Inflammatory factors found in the breast of obese women considerably impact estrogen signaling, mainly by driving changes in aromatase expression the enzyme responsible for estrogen production, and therefore promote tumor formation and progression. There is thus a strong link between adipose inflammation and estrogen biosynthesis and their signaling pathways converge in obese patients. This review describes how obesity-related factors can affect the risk of hormone-dependent breast cancer, highlighting the different molecular mechanisms and metabolic pathways involved in aromatase regulation, estrogen production and breast malignancy in the context of obesity. (C) 2017 Elsevier B.V. All rights reserved.
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