期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 465, 期 C, 页码 92-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.09.001
关键词
Androgen receptor (AR); Sex differences; Testosterone; Hypothalamus; Central nervous system (CNS); Metabolism; Obesity; Insulin resistance; Polycystic ovarian syndrome (PCOS); Arcuate nucleus (ARC)
资金
- National Institutes of Health [DK074970, DK107444]
- American Diabetes Association [7-13-BS-101]
- VA Merit Review Award [BX003725]
The male hormone testosterone exerts different effects on glucose and energy homeostasis in males and females. Testosterone deficiency predisposes males to visceral obesity, insulin resistance and type 2 diabetes. However, testosterone excess predisposes females to similar metabolic dysfunction. Here, we review the effects of testosterone actions in the central nervous system on metabolic function in males and females. In particular, we highlight changes within the hypothalamus that control glucose and energy homeostasis. We distinguish the organizational effects of testosterone in the programming of neural circuitry during development from the activational effects of testosterone during adulthood. Finally, we explore potential sites where androgen might be acting to impact metabolism within the central nervous system. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据