期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 463, 期 C, 页码 72-86出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.08.006
关键词
cAMP; PKA; Pituitary gland; Second messenger; Somatotropinoma; Pituitary adenoma
资金
- Intramural Research Program, NICHD, NIH
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD008920] Funding Source: NIH RePORTER
The cyclic 3',5'-adenosine monophosphate (CAMP) was the first among the so-called second messengers to be described. It is conserved in most organisms and functions as a signal transducer by mediating the intracellular effects of multiple hormones and neurotransmitters. In this review, we first delineate how different members of the cAMP pathway ensure its correct compartmentalization and activity, mediate the terminal intracellular effects, and allow the crosstalk with other signaling pathways. We then focus on the pituitary gland, where cAMP exerts a crucial function by controlling the responsiveness of the cells to hypothalamic hormones, neurotransmitters and peripheral factors. We discuss the most relevant physiological functions mediated by cAMP in the different pituitary cell types, and summarize the defects affecting this pathway that have been reported in the literature. We finally discuss how a deregulated cAMP pathway is involved in the pathogenesis of pituitary disorders and how it affects the response to therapy. (C) 2017 Published by Elsevier Ireland Ltd.
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