期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 462, 期 -, 页码 82-92出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.01.012
关键词
Fatty acids; Cancer; Lipid metabolism; FOXO3; FOXM1; AKT/PI3K pathway
资金
- Medical Research Council (MRC) of UK [MR/N012097/1]
- MRC [MR/N012097/1]
- CRUK [A12011]
- Breast Cancer Now [2012MayPR070, 2012NovPhD016]
- Commonwealth Scholarship Commission [BDCS-2015-63]
- Medical Research Council [MR/N012097/1] Funding Source: researchfish
Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance. Free fatty acids (FFAs), FA synthesis and beta-oxidation are associated with cancer development and progression. Meanwhile, insulin and some adipokines, that are up-regulated by FAs, are also involved in cancer development and poor prognosis. In this review, we discuss the role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis These new insights may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance. (C) 2017 Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据