期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 38, 期 12, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00070-18
关键词
mRNA translation; mTOR; MAPK; MNK; RSK; eIF4E; signal transduction; mRNA; mitogen-activated protein kinases; protein phosphorylation; translational control
资金
- Prostate Cancer Canada
- Cancer Research Society
- Canadian Cancer Society Research Institute
- Canadian Institutes of Health Research
- Terry Fox Research Institute
- National Institutes of Health
- Joint Canada-Israel Health Research Program
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Human Frontier Science Program (HFSP)
Translation is a key step in the regulation of gene expression and one of the most energy-consuming processes in the cell. In response to various stimuli, multiple signaling pathways converge on the translational machinery to regulate its function. To date, the roles of phosphoinositide 3-kinase (PI3K)/AKT and the mitogen-activated protein kinase (MAPK) pathways in the regulation of translation are among the best understood. Both pathways engage the mechanistic target of rapamycin (mTOR) to regulate a variety of components of the translational machinery. While these pathways regulate protein synthesis in homeostasis, their dysregulation results in aberrant translation leading to human diseases, including diabetes, neurological disorders, and cancer. Here we review the roles of the PI3K/AKT and MAPK pathways in the regulation of mRNA translation. We also highlight additional signaling mechanisms that have recently emerged as regulators of the translational apparatus.
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