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Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit
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Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
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Selective β2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac
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Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism
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cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway
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Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac
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BIOCHEMICAL JOURNAL (2013)
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FEBS LETTERS (2013)
Biophysical Techniques for Detection of cAMP and cGMP in Living Cells
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Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The Epac1 Signaling Pathway Regulates Cl- Secretion via Modulation of Apical KCNN4c Channels in Diarrhea
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF
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ONCOGENE (2013)
Evidence for a Pro-Proliferative Feedback Loop in Prostate Cancer: The Role of Epac1 and COX-2-Dependent Pathways
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PLOS ONE (2013)
Opposing Roles of pka and epac in the cAMP-Dependent Regulation of Schwann Cell Proliferation and Differentiation
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Targeted activation of PKA and Epac promotes glioblastoma regression in vitro
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A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion
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Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions
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PHARMACOLOGICAL REVIEWS (2013)
The cAMP signaling system inhibits the repair of γ-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
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A Comprehensive Survey of Ras Mutations in Cancer
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Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac
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Gβγ subunits inhibit Epac-induced melanoma cell migration
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CANCER RESEARCH (2010)
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Epac increases melanoma cell migration by a heparan sulfate-related mechanism
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A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis
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Epac inhibits migration and proliferation of human prostate carcinoma cells
M. Grandoch et al.
BRITISH JOURNAL OF CANCER (2009)
The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway
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CANCER LETTERS (2009)
B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins
Maria Grandoch et al.
CELLULAR SIGNALLING (2009)
Gonadotropin-stimulated epidermal growth factor receptor expression in human ovarian surface epithelial cells: involvement of cyclic AMP-dependent exchange protein activated by cAMP pathway
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Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains
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Epac1-Induced Cellular Proliferation in Prostate Cancer Cells Is Mediated by B-Raf/ERK and mTOR Signaling Cascades
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Critical Role of the N-Terminal Cyclic AMP-Binding Domain of Epac2 in Its Subcellular Localization and Function
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Direct Spatial Control of Epac1 by Cyclic AMP
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection
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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2
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Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
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CURRENT OPINION IN PHARMACOLOGY (2007)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
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Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
Y Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state
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Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer
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MOLECULAR BIOSYSTEMS (2005)
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
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FEBS LETTERS (2005)
Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways - Based on the Anniversary Prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the special FEBS meeting in Brussels
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FEBS JOURNAL (2005)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
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Cooperative translational control of gene expression by Ras and Akt in cancer
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TRENDS IN MOLECULAR MEDICINE (2004)
Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
K Lang et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the α3β1 integrin but not the α6β4 integrin
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac
H Rehmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activation of JNK by Epac is independent of its activity as a rap guanine nucleotide exchanger
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells
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BREAST CANCER RESEARCH AND TREATMENT (2003)
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor
S Rangarajan et al.
JOURNAL OF CELL BIOLOGY (2003)
Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP
JB Qiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mutations of the BRAF gene in human cancer
H Davies et al.
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Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion
Y Kashima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic β-cells
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JOURNAL OF PHYSIOLOGY-LONDON (2001)
Regulation and role of adenylyl cyclase isoforms
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ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
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NATURE GENETICS (2000)
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