期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 447, 期 1-2, 页码 77-92出版社
SPRINGER
DOI: 10.1007/s11010-018-3294-z
关键词
cAMP signaling; Breast cancer therapy; Brain cancer; Metastasis; Melanoma; Leukemia; Ovarian cancer; EPAC
类别
资金
- Ministry of Science and Technology, Department of Biotechnology, Govt. of India
- Breast Cancer Alliance Young Investigator Award, USA
- Shiv Nadar Foundation
Cancer remains a global health problem and approximately 1.7million new cancer cases are diagnosed every year worldwide. Although diverse molecules are currently being explored as targets for cancer therapy the tumor treatment and therapy is highly tricky. Secondary messengers are important for hormone-mediated signaling pathway. Cyclic AMP (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2, which exhibit different tissue distribution and is involved in GDP/GTP exchange along with activating Rap1- and Rap2-mediated signaling pathways. EPAC is also known for its dual role in cancer as pro- and anti-proliferative in addition to metastasis. Results after perturbing EPAC activity suggests its involvement in cancer cell migration, proliferation, and cytoskeleton remodeling which makes it a potential therapeutic target for cancer treatments.
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