期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 450, 期 1-2, 页码 75-85出版社
SPRINGER
DOI: 10.1007/s11010-018-3374-0
关键词
Vitamin D3; Calcitriol; Hedgehog signaling; Mouse embryonic fibroblast; TGF-
类别
资金
- American Cancer Society [RSG-13-131-01]
- National Science Foundation [1515808]
- University of Connecticut Research Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1515808] Funding Source: National Science Foundation
Calcitriol, vitamin D3 (VD3), and structurally related VD3 analogues are inhibitors of Hh signaling in multiple contexts and are promising anti-cancer agents in Hh-dependent forms of cancer; however, the cellular mechanisms through which these compounds regulate Hh signal transmission are not clearly defined. Previous studies in this area have implicated both Smoothened, a key mediator of Hh signaling, and the vitamin D receptor (VDR) as potential mediators of Hh inhibition for this class of seco-steroids. We have performed a series of in vitro studies to more fully probe the cellular mechanisms that govern seco-steroid-mediated inhibition of Hh signaling. Our results support a role for both the Hh and VDR pathways in this process, as well as the possibility that other, as yet unidentified proteins, are also central to seco-steroid-mediated inhibition of Hh signaling.
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