期刊
MITOCHONDRION
卷 41, 期 -, 页码 28-36出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.10.008
关键词
Electron transport chain; Metabolism; Innate immunity; Bacterial infection; Pattern-recognition receptors
资金
- IdEx program of the University of Bordeaux [ANR-10-IDEX-03-02]
- German Research Council (DFG) [SA19402/1, SFB-TR84 TP C08]
- German Ministry of Research and Education (BMBF) [031A402 A]
- EU FP-7 ERA-Net (Infect-ERA, HAPLO-Infect)
Upon microbial infection, cells of the innate immune system undergo profound metabolic reprogramming in order to eradicate pathogens, promote inflammation, and eventually restore tissue homeostasis. Mitochondria are at the core of these adaptations, given their dual role as metabolic hubs and innate immune signaling platforms. The mitochondrial electron transport chain (ETC) is very well characterized at the genetic, molecular, structural, and biochemical level. In contrast, the role for mitochondrial ETC and metabolites beyond fulfilling cellular ATP synthesis in innate immune cell biology was not understood until recently. Here we discuss the latest advances in our understanding of immune functions of mitochondria and particularly the mitochondrial respiratory chain.
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