Organocatalyzed Asymmetric Diels-Alder Reactions in Aqueous or Semi-Aqueous Media

Background: The Diels-Alder reaction is one of the most important reactions in organic synthesis. Objective: Recently there has been considerable interest in conducting this important reaction in aqueous or semi-aqueous media using organocatalysts due to the green nature of the water solvent and organocatalysts as well as the special solvent effects of water on organic reactions. Conclusion: This review attempts to summarize the most recent developments in organocatalytic asymmetric Diels-Alder reactions using water as a solvent or a co-solvent.