期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 18, 期 6, 页码 527-550出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666170927112621
关键词
Marine; natural products; discovery; cardiovascular; pharmacology; marine polysaccharide
资金
- National Natural Science Foundation of China [21172271, 81202454]
- Natural Science Foundation of Guang dong Province, China [S2011020001231]
Numerous studies have indicated that marine natural products are one of the most important sources of the lead compounds in drug discovery for their unique structures, various bioactivities and less side effects. In this review, the marine natural products with cardiovascular pharmacological effects reported after 2000 will be presented. Their structural types, relevant biological activities, origin of isolation and information of strain species will be discussed in detail. Finally, by describing our studies as an example, we also discuss the chances and challenges for translating marine-derived compounds into preclinical or clinical trials.
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