期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 18, 期 10, 页码 812-827出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666171002161325
关键词
Cadmium; computational; copper; cyclophellitol; deoxynojirimycin; diabetes; electrophilic; epoxide; fucosidase; galactosidase; glucocerebroside; glucosidase; glycal; homology; hydantocidin; iminosugar; lactam; lactone; mannosidase; metal complex; modeling; molybdenum; natural product; palladium; salacinol; sialidase; silver; transition-state mimic; vanadium; X-ray crystallography; zinc
资金
- Priority Research centre for Chemical Biology & Clinical Pharmacology at the University of Newcastle
- Institute for Glycomics at Griffith University
- Faculty of Science
Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review covers the literature in the past 15 years since our initial review in this journal on neutral glycosidase inhibitors lacking a basic nitrogen found in iminosugars and azasugars or inhibitors that are neutral by virtue of being charge-balanced (zwitterionic). These structurally diverse inhibitors include lactones, lactams, epoxides such as cyclophellitol, and sulfonium ion derivatives of the natural product salacinol. Synthetic efforts toward cyclophillitol, salicinol and derivatives are also highlighted. Importantly, certain metals can inhibit glycosidases and care must be taken to remove residual catalysts from synthetic material to be tested against these enzymes.
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