期刊
MATERNAL AND CHILD NUTRITION: THE FIRST 1,000 DAYS
卷 74, 期 -, 页码 107-120出版社
KARGER
DOI: 10.1159/000348454
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资金
- NICHD NIH HHS [R01 HD-060628, P01 HD047609, R01 HD-065825, R01 HD060628, R01 HD065825, P01 HD-047609] Funding Source: Medline
Epidemiological, clinical, physiological, cellular and molecular evidence suggests the origins of obesity and metabolic dysfunction can be traced back to intrauterine life and supports an important role for maternal nutrition prior to and during gestation in fetal programming. The elucidation of underlying mechanisms is an area of interest and intense investigation. We propose that in addition to maternal nutrition-related processes, it may be important to concurrently consider the potential role of intrauterine stress and stress biology. We frame our arguments in the larger context of an evolutionary-developmental perspective that supports roles for both nutrition and stress as key environmental conditions driving natural selection and developmental plasticity. We suggest that intrauterine stress exposure may interact with the nutritional milieu, and that stress biology may represent an underlying mechanism mediating the effects of diverse intrauterine perturbations, including but not limited to maternal nutritional insults (undernutrition and overnutrition), on brain and peripheral targets of programming of body composition, energy balance homeostasis and metabolic function. We discuss putative maternal-placental-fetal endocrine and immune/inflammatory candidate processes that may underlie the long-term effects of intrauterine stress. Copyright (C) 2013 Nestec Ltd., Vevey/S. Karger AG, Basel
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