期刊
MICROCHIMICA ACTA
卷 185, 期 2, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-017-2644-y
关键词
Nickel nanoparticles; ITO; Hollow graphene balls; Levodopa; Uric acid; Parkinson's disease
资金
- Natural Science Foundation of Heilongjiang Province [LC2015020]
- Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China [2015192]
- Innovative Talent Fund of Harbin city [2016RAQXJ185]
- Science Funds for the Young Innovative Talents of HUST [201604]
The development of novel nanomaterials brings new opportunity and challenge for high sensing detection of biomolecules. The authors describe the preparation of 3-dimentional hollow graphene balls (3D HGBs) using nickel nanoparticles (Ni-NPs) as the template. The Ni-NPs were synthesized by chemical reduction of nickel chloride and then graphene was coated onto their surface via carburization and carbonization. After etching Ni-NPs, 3D HGBs with few layers and a typical size of 100 nm were obtained. They were sprayed onto indium tin oxide glass to obtain a working electrode for electrochemical determination of levodopa in the presence of uric acid. Due to the unique hollow porous structure of the 3D HGBs, the electrode exhibits a sensitivity of 0.69 mu A.mu M-1.cm(-2) and a 1 mu M limit of detection. It is selective, reproducible and stable. It was applied to the determination of levodopa in spiked human plasma samples and it is of potential use in clinical research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据