期刊
MICROCHIMICA ACTA
卷 185, 期 7, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-018-2844-0
关键词
Surface enhanced fluorescence; Synergistic enhancement; AuNPs; Rare earth luminescent ions; Dopamine detection; Catecholamine; Neurotransmitter; Recognizing component; Co-ligand; Spacer
资金
- National Natural Science Foundation of China [21545001]
- Shandong Provincial Natural Science Foundation, China [ZR2018MB031]
- Fundation of Logistics University of PVP [WHJ201601]
A nanoprobe was developed for the fluorometric determination of the neurotransmitter dopamine (DA). It is based on the synergistic enhancement action of citrate and gold nanoparticles (AuNPs) on the luminescence of Tb(III). AuNPs serve as substrates of surface enhanced fluorescence (SEF). Citrate, in turn, acts as a spacer for the SEF effect, a co-ligand of Tb(III) complex, and a recognizing component for DA. The synergistic action of citrate and AuNPs significantly increases the intrinsic green fluorescence of Tb(III) (best measured at excitation/emission peaks of 300/547 nm). Under the optimum conditions, the fluorescence intensity increases linearly in the 3.0 to 200 nM DA concentration ranging (with an R-2 value of 0.9959), and the limit of detection (at S/N = 3) is 0.84 nM. The nanoprobe shows good selectivity for DA among other interfering neurotransmitters, some amino acids and ions. The method was applied to the detection of DA in human serum samples where it gave recoveries ranging from 100.5 to 102.9%.
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