期刊
MICROBIOLOGY-SGM
卷 164, 期 3, 页码 251-259出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000604
关键词
Methylcitrate cycle; bacterial pathogenesis; propionate metabolism; short chain fatty acids; prp operon; antimicrobial target
类别
资金
- BBSRC
- Rosetrees Trust
- Evelyn Trust
- Yousef Jameel Foundation
- EPSRC
- Royal Society
- BBSRC [BB/R005435/1, BB/M019411/1] Funding Source: UKRI
- EPSRC [EP/K039520/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/R005435/1, BB/M019411/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K039520/1] Funding Source: researchfish
Propionate is an abundant catabolite in nature and represents a rich potential source of carbon for the organisms that can utilize it. However, propionate and propionate-derived catabolites are also toxic to cells, so propionate catabolism can alternatively be viewed as a detoxification mechanism. In this review, we summarize recent progress made in understanding how prokaryotes catabolize propionic acid, how these pathways are regulated and how they might be exploited to develop novel antibacterial interventions.
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