期刊
OPTO-ACOUSTIC METHODS AND APPLICATIONS
卷 8800, 期 -, 页码 -出版社
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2033417
关键词
Photoacoustic tomography; angiogenesis; vascular disruption; OXi450; in vivo
Photoacoustic tomography (PAT) is ideally suited to image tissue vasculature and is therefore able to provide functional response data for the pharmacodynamic time course of vascular targeted therapies. We show in a preclinical model of colorectal carcinoma that 40mg/kg of the vascular disrupting agent OXi4503 causes central tumour blood vessel destruction that can be assessed by PAT at 48 hours. This is confirmed with histological haematoxylin and eosin staining. Outward growth of solid tumours is then static until 16 days post-dose whilst vessel regrowth occurs inwardly to repopulate the necrotic core.
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