期刊
METHODS
卷 142, 期 -, 页码 24-29出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2018.02.023
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR) [299429, 388041]
- Canada Research Chair in Spatial Genome Organization (CRC) [950230661]
- Ontario Early Researcher Award [ER13-09-111]
The health of an organism is intimately linked to its ability to repair damaged DNA. Importantly, DNA repair processes are highly dynamic. This highlights the necessity of characterizing DNA repair in live cells. Advanced genome editing and imaging approaches allow us to visualize damaged DNA and its associated factors in real time. Here, we summarize both established and recent methods that are used to induce DNA damage and visualize damaged DNA and its repair in live cells. (C) 2018 Elsevier Inc. All rights reserved.
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