期刊
METABOLOMICS
卷 14, 期 4, 页码 -出版社
SPRINGER
DOI: 10.1007/s11306-018-1339-7
关键词
Microbial metabolism; Microorganisms; Active efflux; Secretion; Metabolic engineering; Metabolic modeling; Systems biology
资金
- Callaghan Innovation and Bioresource Processing Alliance
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
- NNF Center for Biosustainability [Yeast Cell Factories] Funding Source: researchfish
Introduction Microbial cells secrete many metabolites during growth, including important intermediates of the central carbon metabolism. This has not been taken into account by researchers when modeling microbial metabolism for metabolic engineering and systems biology studies. Materials and Methods The uptake of metabolites by microorganisms is well studied, but our knowledge of how and why they secrete different intracellular compounds is poor. The secretion of metabolites by microbial cells has traditionally been regarded as a consequence of intracellular metabolic overflow. Conclusions Here, we provide evidence based on time-series metabolomics data that microbial cells eliminate some metabolites in response to environmental cues, independent of metabolic overflow. Moreover, we review the different mechanisms of metabolite secretion and explore how this knowledge can benefit metabolic modeling and engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据