相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation
Chiara Vidoni et al.
NEUROCHEMISTRY INTERNATIONAL (2018)
Correction of Huntington's Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model
Karolina Pierzynowska et al.
NEUROMOLECULAR MEDICINE (2018)
Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells
Robin S. B. Williams et al.
NEUROPHARMACOLOGY (2018)
Pimozide reduces toxic forms of tau in TauC3 mice via 5′ adenosine monophosphate-activated protein kinase-mediated autophagy
Young Doo Kim et al.
JOURNAL OF NEUROCHEMISTRY (2017)
An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington's disease
Benjamin R. Underwood et al.
JOURNAL OF NEUROLOGY (2017)
Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
Juan Zhao et al.
MOLECULES (2017)
Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system
Mirna Ezzat Sorial et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2017)
Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy
Y. Zhang et al.
NEUROSCIENCE LETTERS (2017)
Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease
Lijuan Zhang et al.
MEDICAL SCIENCE MONITOR (2017)
NOS1 S-nitrosylates PTEN and inhibits autophagy in nasopharyngeal carcinoma cells
Lingqun Zhu et al.
CELL DEATH DISCOVERY (2017)
Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative
Saurabh Gautam et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2017)
Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy
Yuxi Zhang et al.
CELL CHEMICAL BIOLOGY (2017)
Gender difference in valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mice modeling Alzheimer's disease
Zhimin Long et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2016)
Rag GTPase in amino acid signaling
Joungmok Kim et al.
AMINO ACIDS (2016)
Lithium chloride could aggravate brain injury caused by 3-nitropropionic acid
Aleksandra Milutinovic
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2016)
Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease
Hanaa Hibishy Gaballah et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease
Gabriel R. Linares et al.
EXPERIMENTAL NEUROLOGY (2016)
Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development
Juan Perucho et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2016)
Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3
Yan-Jie Guo et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2016)
An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling
Robin S. B. Williams et al.
NEUROPHARMACOLOGY (2016)
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
Brian J. DeBosch et al.
SCIENCE SIGNALING (2016)
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Qiuyang Zheng et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
Brian J. DeBosch et al.
SCIENCE SIGNALING (2016)
Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice
Petr Vodicka et al.
JOURNAL OF HUNTINGTONS DISEASE (2016)
Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
F. M. Menzies et al.
CELL DEATH AND DIFFERENTIATION (2015)
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Mark Schiebler et al.
EMBO MOLECULAR MEDICINE (2015)
Latrepirdine for Alzheimer's disease
Sarah Chau et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)
AMPK at the Nexus of Energetics and Aging
Kristopher Burkewitz et al.
CELL METABOLISM (2014)
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice
Meike Diepenbroek et al.
HUMAN MOLECULAR GENETICS (2014)
Preclinical and Clinical Investigations of Mood Stabilizers for Huntington's Disease: What Have We Learned?
Lisa Scheuing et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)
Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity
Matthias Hoellerhage et al.
NEUROBIOLOGY OF AGING (2014)
Targeting autophagy in neurodegenerative diseases
Rene L. Vidal et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Challenges in the clinical development of PI3K inhibitors
Cristian Massacesi et al.
INOSITOL PHOSPHOLIPID SIGNALING IN PHYSIOLOGY AND DISEASE (2013)
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
Karen Castillo et al.
AUTOPHAGY (2013)
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
Sovan Sarkar
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Calcium channel blockers and dementia
V. Nimmrich et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity
Jungwon Seo et al.
FEBS JOURNAL (2013)
Neuroprotective Effects of Psychotropic Drugs in Huntington's Disease
Edward C. Lauterbach
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Therapeutic Effects of Valproate Combined With Lithium Carbonate on MPTP-Induced Parkinsonism in Mice: Possible Mediation Through Enhanced Autophagy
Xue-zhong Li et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2013)
Lithium Down-regulates Histone Deacetylase 1 (HDAC1) and Induces Degradation of Mutant Huntingtin
Shuai Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse
Kathleen M. Schoch et al.
JOURNAL OF NEUROCHEMISTRY (2013)
High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system
Katherine H. Kim et al.
MOLECULAR GENETICS AND METABOLISM (2013)
Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
Sefika Ozcelik et al.
PLOS ONE (2013)
Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases
P R Bharadwaj et al.
Translational Psychiatry (2013)
Off label use of lithium in the treatment of Huntington's disease: A case series
Vijay Danivas et al.
INDIAN JOURNAL OF PSYCHIATRY (2013)
Pimozide for schizophrenia or related psychoses
Meghana Mothi et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2013)
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
Veronique Schaeffer et al.
BRAIN (2012)
Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease
Constanza J. Cortes et al.
JOURNAL OF NEUROSCIENCE (2012)
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
Ulrike Krueger et al.
NEUROBIOLOGY OF AGING (2012)
Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion
Kohei Shimada et al.
NEUROBIOLOGY OF DISEASE (2012)
Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein
Dan-Mei Lan et al.
NEUROCHEMICAL RESEARCH (2012)
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson et al.
SCIENCE SIGNALING (2012)
Modeling Parkinson's Disease in Primates: The MPTP Model
Gregory Porras et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Microautophagy in mammalian cells Revisiting a 40-year-old conundrum
Dalibor Mijaljica et al.
AUTOPHAGY (2011)
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Xiaojie Zhang et al.
AUTOPHAGY (2011)
Molecular machinery of macroautophagy and its deregulation in diseases
Alan S. L. Wong et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats
Harikesh Kalonia et al.
BRAIN RESEARCH (2011)
Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies
Dee Shen et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2011)
Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications
Magali Breckler et al.
CELLULAR SIGNALLING (2011)
A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
Yuan Tian et al.
FASEB JOURNAL (2011)
Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-beta Production in an Aged Alzheimer's Disease Transgenic Mouse Model
Xin Zhang et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Chaperone-mediated autophagy at a glance
Susmita Kaushik et al.
JOURNAL OF CELL SCIENCE (2011)
Complex Inhibitory Effects of Nitric Oxide on Autophagy
Sovan Sarkar et al.
MOLECULAR CELL (2011)
Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest
Ian G. Ganley et al.
MOLECULAR CELL (2011)
Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier
Daniel Paris et al.
MOLECULAR MEDICINE (2011)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
Smita Majumder et al.
PLOS ONE (2011)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu et al.
SCIENCE (2011)
Regulation of lipid droplets by autophagy
Hanqing Dong et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)
Autophagy in brain ischemia
Alicja Kost et al.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ (2011)
Epac: Defining a New Mechanism for cAMP Action
Martijn Gloerich et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism
J. S. Schneider et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II
A. Friso et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Overview of macroautophagy regulation in mammalian cells
Maryam Mehrpour et al.
CELL RESEARCH (2010)
Autophagy genes as tumor suppressors
Chengyu Liang et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Mammalian autophagy: core molecular machinery and signaling regulation
Zhifen Yang et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
Daniel J. Ho et al.
EXPERIMENTAL NEUROLOGY (2010)
mTOR regulation of autophagy
Chang Hwa Jung et al.
FEBS LETTERS (2010)
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Claudia Rose et al.
HUMAN MOLECULAR GENETICS (2010)
Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases
Maurizio Renna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation
Jennifer S. Carew et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease β- and γ-Secretase via Distinct Mechanisms
Stefan Mitterreiter et al.
JOURNAL OF NEUROSCIENCE (2010)
Autophagy: cellular and molecular mechanisms
Danielle Glick et al.
JOURNAL OF PATHOLOGY (2010)
3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington's Disease: Past, Present and Future
Isaac Tunez et al.
MOLECULES (2010)
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Jose A. Rodriguez-Navarro et al.
NEUROBIOLOGY OF DISEASE (2010)
Prevalence of Diabetes among Men and Women in China
Wenying Yang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar et al.
PHYSIOLOGICAL REVIEWS (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease
Marcelina Malinowska et al.
PLOS ONE (2010)
HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia
Xiao-Wen Liu et al.
PHARMACOLOGICAL RESEARCH (2010)
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
Carol A. Mercer et al.
AUTOPHAGY (2009)
Atg101, a novel mammalian autophagy protein interacting with Atg13
Nao Hosokawa et al.
AUTOPHAGY (2009)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin et al.
CELL (2009)
Autophagy genes and ageing
T. Vellai
CELL DEATH AND DIFFERENTIATION (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial
Clive Ballard et al.
LANCET NEUROLOGY (2009)
Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice
Marcelina Malinowska et al.
MOLECULAR GENETICS AND METABOLISM (2009)
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
Mitsuko Hayashi-Nishino et al.
NATURE CELL BIOLOGY (2009)
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
Yun Zhong et al.
NATURE CELL BIOLOGY (2009)
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
Jingxiang Huang et al.
BIOCHEMICAL JOURNAL (2008)
Regulation of macroautophagy by mTOR and Beclin 1 complexes
Sophie Pattingre et al.
BIOCHIMIE (2008)
Huntington's disease: degradation of mutant huntingtin by autophagy
Sovan Sarkar et al.
FEBS JOURNAL (2008)
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
Taichi Hara et al.
JOURNAL OF CELL BIOLOGY (2008)
Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression
Mala V. Rao et al.
JOURNAL OF NEUROSCIENCE (2008)
JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy
Yongjie Wei et al.
MOLECULAR CELL (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
NATURE CHEMICAL BIOLOGY (2008)
Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions
Deborah Tribouillard-Tanvier et al.
PLOS ONE (2008)
Autophagy is essential for preimplantation development of mouse embryos
Satoshi Tsukamoto et al.
SCIENCE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
A randomised, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial)
Clive Ballard et al.
PLOS MEDICINE (2008)
The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss
Mark E. Bardgett et al.
NEUROPSYCHOPHARMACOLOGY (2008)
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
Sovan Sarkar et al.
HUMAN MOLECULAR GENETICS (2008)
Small molecule regulators of autophagy identified by an image-based high-throughput screen
Lihong Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sodium valproate does not augment Prpsc in murine neuroblastoma cells
Christophe Legendre et al.
NEUROTOXICITY RESEARCH (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
AMP-activated protein kinase -: A universal regulator of autophagy?
Maria Hoyer-Hansen et al.
AUTOPHAGY (2007)
Ambra1 regulates autophagy and development of the nervous system
Gian Maria Fimia et al.
NATURE (2007)
AMP-Activated protein kinase and autophagy
Alfred J. Meijer et al.
AUTOPHAGY (2007)
Autophagy gene-dependent clearance of apoptotic cells during embryonic development
Xueping Qu et al.
CELL (2007)
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Ken Inoki et al.
CELL (2006)
Effect of resveratral on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
Puneet Kumar et al.
BEHAVIOURAL PHARMACOLOGY (2006)
Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses
Ewa Piotrowska et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2006)
Chemotherapeutic approaches for targeting cell death pathways
M. Stacey Ricci et al.
ONCOLOGIST (2006)
Rapamycin alleviates toxicity of different aggregate-prone proteins
Z Berger et al.
HUMAN MOLECULAR GENETICS (2006)
Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
R Köchl et al.
TRAFFIC (2006)
Molecular mechanism and regulation of autophagy
YP Yang et al.
ACTA PHARMACOLOGICA SINICA (2005)
Growing roles for the mTOR pathway
DD Sarbassov et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Autophagy: molecular machinery for self-eating
T Yorimitsu et al.
CELL DEATH AND DIFFERENTIATION (2005)
Lithium induces autophagy by inhibiting inositol monophosphatase
S Sarkar et al.
JOURNAL OF CELL BIOLOGY (2005)
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
S Pattingre et al.
CELL (2005)
Autophagosomes: biogenesis from scratch?
F Reggiori et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
Isei Tanida et al.
AUTOPHAGY (2005)
Recent advances in understanding the cell death pathways activated by anticancer therapy
R Kim
CANCER (2005)
The role of autophagy in cancer development and response to therapy
Y Kondo et al.
NATURE REVIEWS CANCER (2005)
The molecular machinery of autophagy: unanswered questions
DJ Klionsky
JOURNAL OF CELL SCIENCE (2005)
The role of autophagy during the early neonatal starvation period
A Kuma et al.
NATURE (2004)
Autophagy: Many paths to the same end
AM Cuervo
MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
Valproate decreases inositol biosynthesis
G Shaltiel et al.
BIOLOGICAL PSYCHIATRY (2004)
Regulation and role of autophagy in mammalian cells
AJ Meijer et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Autophagy in health and disease: A double-edged sword
T Shintani et al.
SCIENCE (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Autophagy:: molecular mechanisms, physiological functions and relevance in human pathology
G Mariño et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
MG Gutierrez et al.
JOURNAL OF CELL SCIENCE (2004)
The IGF-1/PI3K/Akt pathway prevents short article expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
TN Stitt et al.
MOLECULAR CELL (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Autophagy genes are essential for dauer development and life-span extension in C-elegans
A Meléndez et al.
SCIENCE (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Calcium signalling: Dynamics, homeostasis and remodelling
MJ Berridge et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Valproic acid treatment results in increased accumulation of prion proteins
GM Shaked et al.
ANNALS OF NEUROLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
A common mechanism of action for three mood-stabilizing drugs
RSB Williams et al.
NATURE (2002)
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
B Ravikumar et al.
HUMAN MOLECULAR GENETICS (2002)
Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca2+- and K+-evoked serotonin release
Y Kawata et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Morphine and clonidine activate different K+ channels on rat amygdala neurons
R Murphy et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
T Kirisako et al.
JOURNAL OF CELL BIOLOGY (2000)
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Y Tanaka et al.
NATURE (2000)
Dimebon improves learning in animals with experimental Alzheimer's disease
NN Lermontova et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2000)
分享论文
