期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 29, 期 2, 页码 191-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2014.10.002
关键词
Bladder cancer; Urothelial carcinoma; Mutations; Somatic copy number alterations; Cell cycle; Epigenetics; Molecular subtypes
Classic as well as more recent large-scale genomic analyses have uncovered multiple genes and pathways important for bladder cancer development. Genes involved in cell-cycle control, chromatin regulation, and receptor tyrosine and PI3 kinase-mammalian target of rapamycin signaling pathways are commonly mutated in muscle-invasive bladder cancer. Expression-based analyses have identified distinct types of bladder cancer that are similar to subsets of breast cancer, and have prognostic and therapeutic significance. These observations are leading to novel therapeutic approaches in bladder cancer, providing optimism for therapeutic progress.
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