Design and synthesis of some isoindoline derivatives as analogues of the active anti-inflammatory Indoprofen

Searching new targets for anti-inflammatory drug design, agents with the isoindole skeleton were focused on the basis of preliminary studies of NSAIDs as COX-1 and/or COX-2 enzyme inhibitors. Thus several novel N-substituted isoindoline derivatives as possible biologically active compounds were prepared as analogues of Indoprofen (1) starting from cis-2-[(4-methylphenyl)carbonyl]cyclohexanecarboxylic acid (3) by treatment with primary arylamines.