Synthesis of NSAIDs-Se derivatives as potent anticancer agents

In the present study, a series of NSAIDs-Se derivatives include selenocyanates and diselenides were synthesized and characterized, their anticancer activities against the human cancer cell lines SW480, HeLa, A549, and HepG2 were determined. Interestingly, most of the new compounds showed active in reducing the viability of different cancer lines. Compounds 1a and 1m exhibited higher promising activities than other derivatives. As the most active compound 1a showed IC50 values lower than 20 mu M against the four cancer cell lines, particularly against SW480 with IC50 values below 10 mu m, it shows the potential to be a promising molecular chemotherapeutic agent for colorectal cancer.