期刊
MEDICAL PHYSICS
卷 45, 期 8, 页码 3697-3704出版社
WILEY
DOI: 10.1002/mp.12964
关键词
deep learning; MR-based attenuation correction; transfer learning
资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [1R21EB013770]
PurposeIn this study, we explore the feasibility of a novel framework for MR-based attenuation correction for PET/MR imaging based on deep learning via convolutional neural networks, which enables fully automated and robust estimation of a pseudo CT image based on ultrashort echo time (UTE), fat, and water images obtained by a rapid MR acquisition. MethodsMR images for MRAC are acquired using dual echo ramped hybrid encoding (dRHE), where both UTE and out-of-phase echo images are obtained within a short single acquisition (35s). Tissue labeling of air, soft tissue, and bone in the UTE image is accomplished via a deep learning network that was pre-trained with T1-weighted MR images. UTE images are used as input to the network, which was trained using labels derived from co-registered CT images. The tissue labels estimated by deep learning are refined by a conditional random field based correction. The soft tissue labels are further separated into fat and water components using the two-point Dixon method. The estimated bone, air, fat, and water images are then assigned appropriate Hounsfield units, resulting in a pseudo CT image for PET attenuation correction. To evaluate the proposed MRAC method, PET/MR imaging of the head was performed on eight human subjects, where Dice similarity coefficients of the estimated tissue labels and relative PET errors were evaluated through comparison to a registered CT image. ResultDice coefficients for air (within the head), soft tissue, and bone labels were 0.760.03, 0.96 +/- 0.006, and 0.88 +/- 0.01. In PET quantitation, the proposed MRAC method produced relative PET errors less than 1% within most brain regions. ConclusionThe proposed MRAC method utilizing deep learning with transfer learning and an efficient dRHE acquisition enables reliable PET quantitation with accurate and rapid pseudo CT generation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据