期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 177, 期 -, 页码 30-36出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2018.03.008
关键词
SOX2; Ageing; Biomarker
资金
- Department of Education, University and Research of the Basque Government
- Carlos III Health Institute [PI13/02277, CP16/00039, PI16/01580, DTS16/0184]
- Diputacion Foral Gipuzkoa
- Departments of Industry and Health of the Basque Government
- European Union [CIG 2012/712404, REFBIO13/BIOD/009]
- European Regional Development Fund
SOX2 (Sex-determining region Y box 2) is a transcription factor expressed in several foetal and adult tissues and its deregulated activity has been linked to chronic diseases associated with ageing. Nevertheless, the level of SOX2 expression in aged individuals at the tissue level has not previously been examined. In this work, we show that SOX2 expression decreases significantly in the brain with ageing, in both humans and rodents. The administration of resveratrol for 6 months in mice partly attenuated this reduction. We also identified an age-relateddecline in SOX2 mRNA and protein expression in several other organs, namely, the lung, heart, kidney, spleen and liver, Moreover, peripheral blood mononuclear cells (PBMCs) from elderly expressed lower levels of SOX2 than those from young individuals. Mechanistically, SOX2 expression inversely correlates with p16(Ink4a) levels. Together, these data show a widespread decrease in SOX2 with age, suggesting that the decline in SOX2 expression might be used as a biomarker of ageing.
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