期刊
NATURE REVIEWS IMMUNOLOGY
卷 13, 期 12, 页码 888-902出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3553
关键词
-
类别
资金
- European Research Council
- European Union
- Swiss National Foundation
- Foundation Alliance BioSecure
- Novartis Research Foundation
- Clinical Research Priority Program (KFSP) of the University of Zurich, Switzerland
- Collegio Ghislieri (Pavia, Italy)
- Foundation for Research at the Medical Faculty of the University of Zurich
Individuals infected with prions succumb to brain damage, and prion infections continue to be inexorably lethal. However, many crucial steps in prion pathogenesis occur in lymphatic organs and precede invasion of the central nervous system. In the past two decades, a great deal has been learnt concerning the cellular and molecular mechanisms of prion lymphoinvasion. These properties are diagnostically useful and have, for example, facilitated preclinical diagnosis of variant Creutzfeldt-Jakob disease in the tonsils. Moreover, the early colonization of lymphoid organs can be exploited for post-exposure prophylaxis of prion infections. As stromal cells of lymphoid organs are crucial for peripheral prion infection, the dedifferentiation of these cells offers a powerful means of hindering prion spread in infected individuals. In this Review, we discuss the current knowledge of the immunobiology of prions with an emphasis on how basic discoveries might enable translational strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据