期刊
MATRIX BIOLOGY
卷 71-72, 期 -, 页码 368-379出版社
ELSEVIER
DOI: 10.1016/j.matbio.2018.02.025
关键词
Intervertebral disc; Extracellular matrix; Intervertebral disc degeneration; GAG synthesis; Proteoglycans
资金
- National Institutes of Health [AR055655, AR064733]
- NIH [T32 AR052273]
Few human tissues have functions as closely linked to the composition of their extracellular matrices as the intervertebral disc. In fact, the hallmark of intervertebral disc degeneration, commonly accompanying low back and neck pain, is the progressive loss of extracellular matrix molecules - specifically the GAG-substituted proteoglycans. While this loss is often associated with increased extracellular catabolism via metalloproteinases and pro-inflammatory cytokines, there is strong evidence that disc degeneration is related to dysregulation of the enzymes involved in GAG biosynthesis. In this review, we discuss those environmental factors, unique to the disc, that control expression and function of XT-1, GIcAT-I, and ChSy/ChPF in the healthy and degenerative state. Additionally, we address the pathophysiology of aberrant GAG biosynthesis and highlight therapeutic strategies designed to augment the loss of extracellular matrix molecules that afflict the degenerative state. (C) 2018 Elsevier B.V. All rights reserved.
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