期刊
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
卷 27, 期 4, 页码 409-425出版社
ELSEVIER
DOI: 10.1016/j.bpa.2013.10.008
关键词
angiogenesis; lymphangiogenesis; beta-blocker; NSAID; vasculature; sympathetic nervous system; SNS; nerve fibres
资金
- National Health and Medical Research Council of Australia [1008865, 1049561]
- National Institutes of Health [CA160890]
- Monash Institute of Pharmaceutical Sciences
- UCLA Norman Cousins Center
- Cancer Therapeutics Co-operative Research Centre
The progression of cancer is supported by a wide variety of nonneoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and discusses the potential therapeutic uses of drugs that target angiogenesis, lymphangiogenesis and stress-response pathways in the different stages of cancer care. (C) 2013 Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据