期刊
GENOMICS DATA
卷 1, 期 -, 页码 2-6出版社
ELSEVIER
DOI: 10.1016/j.gdata.2013.06.001
关键词
Vincristine; microRNAs; ESTs; Computational prediction; C. roseus
No study has been performed on identifying microRNAs (miRNAs) and their targets in the medicinal plant, Catharanthus roseus. In the present study, using the comparative genomics approach, we have predicted two potential C. roseus miRNAs. Furthermore, twelve potential mRNA targets were identified in C. roseus genome based on the characteristics that miRNAs exhibit perfect or nearly perfect complementarity with their targeted mRNA sequences. Among them many of the targets were predicted to encode enzymes that regulate the biosynthesis of terpenoid indole alkaloids (TIA). In addition, most of the predicted targets were the gene coding for transcription factors which are mainly involved in cell growth and development, signaling and metabolism. This is the first in silico study to indicate that miRNA target gene encoding enzymes involved in vinblastine and vincristine biosynthesis, which may help to understand the miRNA-mediated regulation of TIA alkaloid biosynthesis in C. roseus. (C) 2013 The Authors. Published by Elsevier Inc. Open access under CC BY-NC-ND license.
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