期刊
BIOMOLECULES
卷 3, 期 4, 页码 741-777出版社
MDPI
DOI: 10.3390/biom3040741
关键词
biocatalysis; enzymatic processes; chiral intermediates; drugs development
Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has become increasingly important in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived there from for the transformation of synthetic chemicals with high chemo-, regio-and enatioselectivities. In this article, biocatalytic processes are described for the synthesis of chiral alcohols and unntural aminoacids for pharmaceuticals.
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