期刊
MATERIALS TECHNOLOGY
卷 33, 期 4, 页码 276-287出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10667857.2018.1432171
关键词
Antibacterial; curcumin; electrogelation; silk fibroin; wound dressing
资金
- Hacettepe University
Recently, silk fibroin gel systems (e-gel), formed with weak electric fields have been prepared for various tissue-engineering applications such as neural, cartilage and bone. Here, we demonstrated the effectiveness of an electroresponsive silk fibroin (SF) hydrogel, which is a 3-D scaffold formed and used as a wound dressing material. SEM studies revealed that the curcumin (CUR)-loaded SF (CUR-SF) consisted of a 3-D porous structure with a porosity percent of 80% and a swelling ratio over 100%. Colony forming unit assay confirmed that CUR-SF e-gel scaffolds produced a reduction in viable bacteria compared to bare SF scaffolds. In vitro studies performed with immortalized human keratinocyte (HaCaT) indicated no toxicity of CUR-loaded SF e-gel scaffolds to healthy cells. Taking all the results together, it was suggested that the CUR-SF e-gel scaffolds could improve the wound healing activity in comparison to SF without curcumin and be potentially used as a wound dressing material.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据