期刊
DRUG DISCOVERIES AND THERAPEUTICS
卷 7, 期 6, 页码 233-242出版社
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2013.v7.6.233
关键词
Histone deacetylases; HDAC6; cancer; inhibitor
资金
- national high technology research and development program of China (863 project) [2007AA02Z314]
- National Science and Technology Major Project [2009ZX09103-118]
Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development and metastasis through tubulin, HSP90, invasin and ubiquitin-protein. Here we review the structure elements, biological function, and recent selective inhibitors of HDAC6, and study the structure-activity and structure-selectivity relationship.
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