期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 91, 期 -, 页码 94-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.05.033
关键词
Electrospinning; Halloysite nanotubes; Nanofibers; Biocompatibility; Polymer nanocomposite
资金
- Ministry of Education, Youth and Sports of the Czech Republic under the National Sustainability Programme II [LQ1601]
- European Regional Development Fund [CZ.1.05/2.1.00/03.0086]
- Ministry of Education Youth and Sports of Czech Republic [L01411]
- Slovak Research and Development Agency [APW-14-0175]
- Ministry of Health of the Czech Republic [17-29874A]
Nanofibrous elastic material based on the blend of hydrophobic poly(epsilon-caprolactone) (PCL) and hydrophilic gelatin (Gel) reinforced with halloysite nanotubes (HNTs) was prepared by electrospinning process by respecting principles of green chemistry required for tissue engineering and drug delivery carriers. Three different kinds of HNTs with similar aspect ratio, but different length and inner diameter were examined to explain the effect of HNT concentration and geometry on a structure, morphology, chemical composition, mechanical properties and biocompatibility of nanostructured materials. Reinforcing effect of each type of HNTs has been confirmed up to 6 wt%. However, the highest improvement of mechanical properties was exhibited by addition just 0.5 wt% of HNTs. All HNT modified nanofibers have been confirmed as non-cytotoxic based on the interaction with mouse fibroblasts NIH-3T3 cells and therefore suitable for biomedical applications, e.g. as wound healing coverings with controlled drug delivery.
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