期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 91, 期 -, 页码 26-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.05.024
关键词
Electrospinning; Electrospraying; Nanofibers; Nanoparticles; Zein; Ethyl cellulose; Polyethylene oxide; Drug release
资金
- Fundamental Research Funds for the Central Universities [JUSRP51621A, JUSRP51505, JUSRP115A04]
- Six Talent Peaks Project in Jiangsu Province [2014-XCL001]
- National First-Class Discipline Program of Light Industry Technology and Engineering [LITE2018-21]
- 111 Project [B17021]
- Innovation Program for Graduate Education in Jiangsu Province [KYLX16_0795]
Electrohydrodynamic method was used to produce both single-drug and dual-drug loaded nanocomposites. Zein was blended with ethyl cellulose, and the mixture was electrospun into nanofibers. Polyethylene oxide was electroprayed into nanoparticles and deposited on the nanofibrous matrix. Indomethacin and tetracycline hydrochloride were loaded in the nanocomposites as model drugs. The suitable electrospraying conditions were chosen based on the result of scanning electron microscopy. Fourier transform infrared spectra indicated that components were merely physically combined. Differential scanning calorimetry and X-ray diffraction confirmed amorphous states of the drugs in the nanocomposites. The nanocomposites displayed good wettability, water-stability and improved modulus. In vitro dissolution tests revealed a desirable drug release profile, which abided by Fickian diffusion.
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