期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 92, 期 -, 页码 995-1005出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.06.065
关键词
Polyester materials; Cell microenvironment; Electrospun aligned nanofiber; Stem cells; Tissue regeneration
资金
- National Natural Science Foundation of China [31600804, 11532009]
- Natural Science Basic Research Plan in the Shaanxi Province of China [2017JM8097, 2017JQ3035]
- National Project Cultivating Foundation of Xi'an Medical University [2017GJFY23]
- China Postdoctoral Science Foundation [2018T111071, 2016M592799]
- Fundamental Research Funds for the Central Universities [xjj2016081]
- Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2017LHM-KFKT005]
Engineered tissue constructs rely on biomaterials as support structures for tissue repair and regeneration. Among these biomaterials, polyester biomaterials have been widely used for scaffold construction because of their merits such as ease in synthesis, degradable properties, and elastomeric characteristics. To mimic the aligned structures of native extracellular matrix (ECM) in tissues such as nerve, heart and tendon, various polyester materials have been fabricated into aligned fibrous scaffolds with fibers ranging from several nanometers to several micrometers in diameter by electrospinning in a simple and reproducible manner. These aligned fibrous scaffolds, especially the three-dimensional (3D) aligned nanofibrous scaffolds have emerged as a promising solution for tissue regeneration. Compared with two-dimensional (2D) scaffolds, the 3D aligned nanofibrous scaffolds provide another dimension for cell behaviors such as morphogenesis, migration and cell cell interactions, which is important in regulating the stem cell fate and tissue regeneration. In this review, we provide an extensive overview on recent efforts for constructing 3D aligned polyester nanofibrous scaffolds by electrospinning, then the results of cell-specific functions dependent on such physical and chemical cues, and discuss their potentials in improving or restoring damaged tissues.
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